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A Phase 3, Randomized, Double-blinded, Placebo-controlled, Multicenter Study to Evaluate Efficacy and Safety of ALXN1850 (Recombinant Alkaline Phosphatase) Administered Subcutaneously in Adolescent (12 to < 18 Years of Age) and Adult Participants With Hypophosphatasia Who Have Not Previously Been Treated With Asfotase Alfa

Trial Profile

A Phase 3, Randomized, Double-blinded, Placebo-controlled, Multicenter Study to Evaluate Efficacy and Safety of ALXN1850 (Recombinant Alkaline Phosphatase) Administered Subcutaneously in Adolescent (12 to < 18 Years of Age) and Adult Participants With Hypophosphatasia Who Have Not Previously Been Treated With Asfotase Alfa

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 31 May 2025

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At a glance

  • Drugs Efzimfotase alfa (Primary)
  • Indications Hypophosphatasia
  • Focus Registrational; Therapeutic Use
  • Acronyms HICKORY
  • Sponsors Alexion AstraZeneca Rare Disease

Most Recent Events

  • 15 Apr 2025 Planned End Date changed from 29 Mar 2028 to 29 May 2029.
  • 20 Mar 2025 Planned primary completion date changed from 6 Aug 2025 to 11 Jul 2025.
  • 20 Feb 2025 Planned primary completion date changed from 24 Jul 2025 to 6 Aug 2025.

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