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A Phase 3, Randomized, Open-label, Parallel-arm, Active-controlled, Multicenter Study to Evaluate Safety and Efficacy of ALXN1850 Versus Asfotase Alfa Administered Subcutaneously in Pediatric Participants (2 to < 12 Years of Age) With Hypophosphatasia (HPP) Previously Treated With Asfotase Alfa

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A Phase 3, Randomized, Open-label, Parallel-arm, Active-controlled, Multicenter Study to Evaluate Safety and Efficacy of ALXN1850 Versus Asfotase Alfa Administered Subcutaneously in Pediatric Participants (2 to < 12 Years of Age) With Hypophosphatasia (HPP) Previously Treated With Asfotase Alfa

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 08 Feb 2025

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At a glance

  • Drugs Efzimfotase alfa (Primary) ; Asfotase alfa
  • Indications Hypophosphatasia
  • Focus Adverse reactions; Registrational
  • Acronyms CHESTNUT
  • Sponsors Alexion AstraZeneca Rare Disease

    • Most Recent Events

    • 31 Jan 2025 Planned End Date changed from 24 Jan 2028 to 1 Mar 2028.
    • 31 Jan 2025 Planned primary completion date changed from 16 Jun 2025 to 29 Jul 2025.
    • 27 Aug 2024 Planned End Date changed from 15 Oct 2027 to 24 Jan 2028.

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