Trial Profile

A Randomized Phase 2b/Phase 3 Study of the TGF-β2 Targeting Antisense Oligonucleotide OT-101 in Combination With mFOLFIRINOX Compared With mFOLFIRINOX Alone in Patients With Advanced and Unresectable or Metastatic Pancreatic Cancer

Status: Recruiting

Phase of Trial: Phase II/III

Latest Information Update: 06 Aug 2025

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At a glance

Drugs Trabedersen (Primary) ; Fluorouracil; Folinic acid; Irinotecan; Oxaliplatin
Indications Adenocarcinoma; Pancreatic cancer
Focus Registrational; Therapeutic Use
Acronyms STOP-PC
Sponsors Mateon Therapeutics; Oncotelic Therapeutics

17 Jul 2025 According to a Oncotelic Therapeutics media release, data from this study has been published in the International Journal of Molecular Sciences (IJMS).
13 Mar 2024 Planned number of patients changed from 468 to 455.
13 Mar 2024 Planned initiation date changed from 1 Dec 2023 to 1 May 2024.

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