Trial Profile

A Phase 2, Open-label, Multicenter, Randomized Study to Evaluate the Persistence, Safety, Acceptability, and Pharmacokinetics of Twice Yearly Long-acting Subcutaneous Lenacapavir for HIV Pre-Exposure Prophylaxis (PrEP) in People Who Would Benefit From PrEP

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 26 Jun 2025

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At a glance

Drugs Lenacapavir (Primary) ; Lenacapavir (Primary) ; Emtricitabine/tenofovir disoproxil fumarate
Indications HIV infections
Focus Therapeutic Use
Acronyms PURPOSE 5
Sponsors Gilead Sciences

22 Jun 2025 Planned End Date changed from 1 Jul 2029 to 1 Dec 2028.
22 Jun 2025 Planned primary completion date changed from 1 Jan 2027 to 1 May 2026.
22 Jun 2025 Status changed from recruiting to active, no longer recruiting.

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