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Multi-Center Phase I Study of Avutometinib (VS-6766), a RAF/MEK Clamp in Combination With Defactinib, a FAK Inhibitor, in Pediatric Patients With Refractory or Recurrent Solid Tumors Harboring Activating MAPK Pathway or NF2 Alterations

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Trial Profile

Multi-Center Phase I Study of Avutometinib (VS-6766), a RAF/MEK Clamp in Combination With Defactinib, a FAK Inhibitor, in Pediatric Patients With Refractory or Recurrent Solid Tumors Harboring Activating MAPK Pathway or NF2 Alterations

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 03 Mar 2026

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At a glance

  • Drugs Avutometinib (Primary)
  • Indications Glioma; Neuroblastoma; Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 25 Feb 2026 Planned number of patients changed from 24 to 23.
  • 31 Oct 2023 New trial record

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