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A Phase III Randomized Controlled Trial to Compare BL-B01D1 With Physician's Choice of Chemotherapy (Last Line) in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC) Previously Treated With PD-1/PD-L1 Monoclonal Antibody and at Least Two Lines of Chemotherapy (at Least One Line of Platinum-based Chemotherapy)

Trial Profile

A Phase III Randomized Controlled Trial to Compare BL-B01D1 With Physician's Choice of Chemotherapy (Last Line) in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC) Previously Treated With PD-1/PD-L1 Monoclonal Antibody and at Least Two Lines of Chemotherapy (at Least One Line of Platinum-based Chemotherapy)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 13 Oct 2025

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At a glance

  • Drugs Izalontamab brengitecan (Primary) ; Capecitabine; Docetaxel; Gemcitabine
  • Indications Carcinoma; Nasopharyngeal cancer
  • Focus Registrational; Therapeutic Use
  • Sponsors Sichuan Baili Pharmaceutical

Most Recent Events

  • 30 Sep 2025 Planned End Date changed from 1 Dec 2027 to 1 Nov 2026.
  • 26 Sep 2025 Planned End Date changed from 1 Dec 2025 to 1 Nov 2026.
  • 26 Sep 2025 Planned primary completion date changed from 1 Dec 2025 to 1 Dec 2027 .

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