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A Phase 1, Multicenter, Open-Label Study of CB-012, a CRISPR-Edited Allogeneic Anti-CLL-1 CAR-T Cell Therapy in Patients With Relapsed/Refractory Acute Myeloid Leukemia

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Trial Profile

A Phase 1, Multicenter, Open-Label Study of CB-012, a CRISPR-Edited Allogeneic Anti-CLL-1 CAR-T Cell Therapy in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 13 May 2025

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At a glance

  • Drugs CB 012 (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Acute myeloid leukaemia
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms AMpLify
  • Sponsors Caribou Biosciences

Most Recent Events

  • 07 May 2025 Status changed from recruiting to active, no longer recruiting.
  • 04 Jun 2024 Trial design presented at the 60th Annual Meeting of the American Society of Clinical Oncology
  • 04 Jan 2024 Status changed from not yet recruiting to recruiting.

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