Trial Profile

A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Intravenously Administered PYC-003, a Peptide-phosphorodiamidate Morpholino Oligonucleotide Conjugate, in Healthy Adult Participants and Adult Participants With Confirmed PKD1 Mutation-associated Autosomal Dominant Polycystic Kidney Disease

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 04 Aug 2026

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At a glance

08 Jun 2026 Planned number of patients changed from 116 to 166.
08 Jun 2026 Planned End Date changed from 1 Mar 2027 to 1 Nov 2028.
08 Jun 2026 Planned primary completion date changed from 1 Sep 2026 to 1 Nov 2028.

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