Trial Profile

PROMIZE: A Phase I/II Trial to Assess the Safety, Tolerability and Preliminary Anti-tumour Activity of Oral Combination Antibiotic Therapy to Modulate the Microbiome in Combination With Enzalutamide With Metastatic Castration Resistant Prostate Cancer (mCRPC)

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 26 Nov 2025

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At a glance

Drugs Amoxicillin (Primary) ; Ciprofloxacin (Primary) ; Enzalutamide (Primary) ; Metronidazole (Primary) ; Vancomycin (Primary)
Indications Adenocarcinoma; Prostate cancer
Focus Adverse reactions; Therapeutic Use
Acronyms PROMIZE

24 Apr 2025 Planned End Date changed from 31 Jul 2025 to 30 Jun 2027.
24 Apr 2025 Planned primary completion date changed from 30 Jun 2024 to 30 Jun 2026.
17 Nov 2023 New trial record

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