Trial Profile

Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination with the PARP Inhibitor Olaparib in Patients with KRAS G12C Mutated Advanced Solid Tumors, with a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 13 Apr 2026

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At a glance

Drugs Adagrasib (Primary) ; Olaparib (Primary)
Indications Advanced breast cancer; Gynaecological cancer; Male breast cancer; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours; Uterine cancer
Focus Adverse reactions

09 Apr 2026 Status changed from recruiting to discontinued because sponsor stopped the trial.
01 Apr 2026 Planned End Date changed from 25 Aug 2030 to 31 Dec 2026.
01 Apr 2026 Actual Primary Completion Date is 14 Jun 2024.

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