Trial Profile

Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination with the PARP Inhibitor Olaparib in Patients with KRAS G12C Mutated Advanced Solid Tumors, with a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 25 Apr 2025

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At a glance

Drugs Adagrasib (Primary) ; Olaparib (Primary)
Indications Advanced breast cancer; Gynaecological cancer; Male breast cancer; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours; Uterine cancer
Focus Adverse reactions

22 Apr 2025 Planned primary completion date changed from 25 Aug 2030 to 25 Aug 2028.
30 Jul 2024 Planned primary completion date changed from 25 Aug 2028 to 25 Aug 2030.
30 Jan 2024 Status changed from not yet recruiting to recruiting.

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