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Randomized, Open-label, Multicenter, Phase 3 Trial of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

Trial Profile

Randomized, Open-label, Multicenter, Phase 3 Trial of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 20 May 2025

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At a glance

  • Drugs Repotrectinib (Primary) ; Crizotinib
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms TRIDENT-3
  • Sponsors Bristol-Myers Squibb

Most Recent Events

  • 06 May 2025 Planned number of patients changed from 230 to 190.
  • 06 May 2025 Planned End Date changed from 27 Jan 2031 to 3 Jun 2027.
  • 06 May 2025 Planned primary completion date changed from 26 Feb 2029 to 3 Jun 2027.

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