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A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled and Deucravacitinib Active Comparator-controlled Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

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Trial Profile

A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled and Deucravacitinib Active Comparator-controlled Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 10 Apr 2026

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At a glance

  • Drugs Icotrokinra (Primary) ; Deucravacitinib
  • Indications Plaque psoriasis
  • Focus Registrational; Therapeutic Use
  • Acronyms ICONIC-ADVANCE 1
  • Sponsors Janssen Research & Development

Most Recent Events

  • 28 Mar 2026 According to Johnson & Johnson Media Release, data from this trial is being presented at the 2026 American Academy of Dermatology (AAD) Annual Meeting.
  • 28 Mar 2026 Results presented in the Johnson & Johnson Media Release.
  • 18 Mar 2026 According to Johnson & Johnson Media Release, company announced today that the U.S. Food and Drug Administration (FDA) has approved ICOTYDE™ (icotrokinra), an interleukin-23 (IL-23) receptor antagonist for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients 12 years of age and older who weigh at least 40 kg who are candidates for systemic therapy or phototherapy.

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