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A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled and Deucravacitinib Active Comparator-controlled Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

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A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled and Deucravacitinib Active Comparator-controlled Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Mar 2025

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At a glance

  • Drugs Icotrokinra (Primary) ; Deucravacitinib
  • Indications Plaque psoriasis
  • Focus Registrational; Therapeutic Use
  • Acronyms ICONIC-ADVANCE 1
  • Sponsors Janssen Research & Development

    • Most Recent Events

    • 08 Mar 2025 Primary endpoint (JNJ-77242113 and Placebo Group: Percentage of Participants Achieving Psoriasis Area and Severity Index (PASI) 90 Response at Week 16) has been met.
    • 08 Mar 2025 Primary endpoint (JNJ-77242113 and Placebo Group: Percentage of Participants Achieving an Investigator's Global Assessment (IGA) Score of 0 or 1 and Greater Than or Equal to () 2-Grade Improvement From Baseline to Week 16) has been met.
    • 08 Mar 2025 Results published in the Johnson & Johnson Media Release.

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