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A First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ 88549968, a T-cell Redirecting Bispecific Antibody for CALR-mutated Myeloproliferative Neoplasms

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Trial Profile

A First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ 88549968, a T-cell Redirecting Bispecific Antibody for CALR-mutated Myeloproliferative Neoplasms

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 15 Sep 2026

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At a glance

  • Drugs JNJ-88549968 (Primary)
  • Indications Essential thrombocythaemia; Myelofibrosis
  • Focus Adverse reactions; First in man
  • Sponsors Janssen Research & Development; Janssen-Cilag

Most Recent Events

  • 10 Sep 2026 Planned number of patients changed from 220 to 300.
  • 06 Jul 2026 Planned number of patients changed from 220 to 241.
  • 06 Jul 2026 Planned End Date changed from 12 May 2028 to 14 Jun 2028.

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