Trial Profile

A Phase 1, Study of VX-828 in Healthy Subjects and in Subjects With Cystic Fibrosis

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 09 Oct 2025

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At a glance

Drugs Deutivacaftor (Primary) ; Ivacaftor/tezacaftor (Primary) ; VX 118 (Primary) ; VX 828 (Primary) ; Itraconazole; Midazolam
Indications Cystic fibrosis
Focus Adverse reactions; Pharmacokinetics
Sponsors Vertex Pharmaceuticals

Most Recent Events

18 Sep 2025 Planned End Date changed from 5 Feb 2026 to 23 Apr 2026.
18 Sep 2025 Planned primary completion date changed from 5 Feb 2026 to 23 Apr 2026.
30 May 2025 Planned number of patients changed from 225 to 255.

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