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Neoadjuvant/Phase 1 Study of CD40 Agonist (LVGN7409) and PD-1 Inhibitor (LVGN3616) in Patients With Resectable HPV-negative Head/Neck Squamous Cell Carcinoma (HNSCC)

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Trial Profile

Neoadjuvant/Phase 1 Study of CD40 Agonist (LVGN7409) and PD-1 Inhibitor (LVGN3616) in Patients With Resectable HPV-negative Head/Neck Squamous Cell Carcinoma (HNSCC)

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 02 Jan 2026

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At a glance

  • Drugs Dalnicastobart (Primary) ; Pradusinstobart (Primary) ; Nivolumab
  • Indications Carcinoma; Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Oropharyngeal cancer; Squamous cell cancer
  • Focus Pharmacodynamics

Most Recent Events

  • 12 Sep 2025 Status changed from recruiting to active, no longer recruiting.
  • 19 Jul 2024 Status changed from not yet recruiting to recruiting.
  • 04 Jun 2024 Planned initiation date changed from 1 May 2024 to 1 Jul 2024.

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