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A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Adult Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications

Trial Profile

A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Adult Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 26 May 2025

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At a glance

  • Drugs Zilebesiran (Primary)
  • Indications Hypertension
  • Focus Therapeutic Use
  • Acronyms KARDIA-3
  • Sponsors Alnylam Pharmaceuticals

Most Recent Events

  • 20 Jan 2025 Status changed from recruiting to active, no longer recruiting.
  • 12 Jan 2025 According to Alnylam Pharmaceuticals media release, company plans to report results from the KARDIA-3 Phase 2 study in the second half of 2025.
  • 03 Jun 2024 KARDIA-3 will initiate enrollment in early 2024, according to trial design in presented 33rd European meeting on hypertension and cardiovascular protection.

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