A Multicenter, Open-Label, Single-Arm, Phase II Trial Exploring the Maintenance of Trastuzumab and Pertuzumab Following Trastuzumab Deruxtecan as Induction Treatment for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer
Latest Information Update: 15 Sep 2026
At a glance
- Drugs Pertuzumab/trastuzumab (Primary) ; Trastuzumab-deruxtecan (Primary)
- Indications Advanced breast cancer; HER2 positive breast cancer
- Focus Therapeutic Use
- Acronyms DEMETHER
Most Recent Events
- 29 Apr 2026 Planned End Date changed from 1 May 2029 to 1 Jun 2029.
- 29 Apr 2026 Planned primary completion date changed from 1 Nov 2026 to 1 Apr 2027.
- 29 Apr 2026 Status changed from recruiting to active, no longer recruiting.