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Infusional FOLFOX Plus Camrelizumab and Apatinib Versus HAIC-FOLFOX Plus Camrelizumab and Apatinib for Hepatocellular Carcinoma of BCLC C Stage: A Multi-center Randomized Phase III Trial

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Trial Profile

Infusional FOLFOX Plus Camrelizumab and Apatinib Versus HAIC-FOLFOX Plus Camrelizumab and Apatinib for Hepatocellular Carcinoma of BCLC C Stage: A Multi-center Randomized Phase III Trial

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 02 Jan 2026

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At a glance

  • Drugs Camrelizumab (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; Oxaliplatin (Primary) ; Rivoceranib (Primary)
  • Indications Liver cancer
  • Focus Therapeutic Use

Most Recent Events

  • 03 Dec 2025 Primary end-points are amended to add "Hepatic Reserve Function Impairment Rate(ICG-15min)" and "6-month PFSR" while "ORR" is removed from primary end-points.
  • 03 Dec 2025 Planned number of patients changed from 192 to 262.
  • 03 Dec 2025 Planned End Date changed from 31 Jul 2027 to 31 Jul 2029.

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