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A Single-arm, Open-label, Dose Exploratory Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Autologous Humanized MAGE-A4-directed T Cell Receptor Engineered T Cell (JWTCR001) in Patients With Advanced Solid Tumors

Trial Profile

A Single-arm, Open-label, Dose Exploratory Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Autologous Humanized MAGE-A4-directed T Cell Receptor Engineered T Cell (JWTCR001) in Patients With Advanced Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 09 Dec 2024

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At a glance

  • Drugs JWTCR 001 (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 03 Dec 2024 According to a Medigene AG media release, company announced a USD $1 million milestone payment from Regeneron Pharmaceuticals, Inc. was triggered. The payment was triggered by a development milestone for a trial in China led by JW Therapeutics (also a prior collaborator of 2seventy bio, Inc.) of Regeneron's MAGE-A4 cell therapy, which contains a Medigene generated T cell receptor (TCR) targeting MAGE-A4.
  • 19 Dec 2023 New trial record

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