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Phase 1 Proof-of-Concept Study to Evaluate the Safety and Immunogenicity of a Priming VaccinationRegimen of Uvax Bio's Glycan Trimmed HIV-1 Vaccine (UVAX-1107) With CpG 1018/Aluminum HydroxideAdjuvant in Healthy Adults (25-55 Years), Followed by Boosting Vaccination Regimen Using UVAX-1107 orWildtype Non-Glycan Trimmed HIV-1 Vaccine (UVAX-1197) With CpG 1018/Aluminum Hydroxide Adjuvant

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Trial Profile

Phase 1 Proof-of-Concept Study to Evaluate the Safety and Immunogenicity of a Priming VaccinationRegimen of Uvax Bio's Glycan Trimmed HIV-1 Vaccine (UVAX-1107) With CpG 1018/Aluminum HydroxideAdjuvant in Healthy Adults (25-55 Years), Followed by Boosting Vaccination Regimen Using UVAX-1107 orWildtype Non-Glycan Trimmed HIV-1 Vaccine (UVAX-1197) With CpG 1018/Aluminum Hydroxide Adjuvant

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 30 May 2025

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At a glance

  • Drugs UVAX 1107 (Primary) ; UVAX 1197 (Primary)
  • Indications HIV-1 infections
  • Focus Adverse reactions; First in man; Pharmacodynamics; Proof of concept
  • Sponsors Uvax Bio

Most Recent Events

  • 23 May 2025 Status changed from active, no longer recruiting to completed.
  • 19 Nov 2024 According to Uvax Bio media release, company to report topline data from a 2nd interim analysis after the first booster vaccination (out of two boosters with UVAX-1107/UVAX-1197/Placebo) for the Phase 1 trial in the first quarter of 2025.
  • 19 Nov 2024 Interim Results presented in the Uvax Bio Media Release.

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