Trial Profile

A Phase I, Open Label, Fixed-sequence Drug Interaction Study to Investigate the Effect of Multiple Oral Doses of LOXO-305 on the Pharmacokinetics of a Single Dose of Intravenous and Oral Midazolam (CYP3A4 Substrate) in Healthy Subjects

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 26 Feb 2025

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At a glance

Drugs Pirtobrutinib (Primary) ; Midazolam; Midazolam
Indications Chronic lymphocytic leukaemia; Haematological malignancies; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
Focus Pharmacokinetics
Sponsors Eli Lilly and Company

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