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A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Orally Administered Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults with Hereditary Angioedema

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Trial Profile

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Orally Administered Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults with Hereditary Angioedema

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 11 Sep 2026

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At a glance

  • Drugs Deucrictibant (Primary) ; Icatibant
  • Indications Hereditary angioedema
  • Focus Registrational; Therapeutic Use
  • Acronyms CHAPTER-3
  • Sponsors Pharvaris

Most Recent Events

  • 08 Sep 2026 According to a Pharvaris media release, Marc A. Riedl, M.D., M.S., Professor of Medicine is the principal investigator in the CHAPTER-3 study.
  • 08 Sep 2026 According to a Pharvaris media release, data from the CHAPTER-3 study will serve as the basis for marketing authorization applications, which are planned to be submitted starting in the first half of 2027.
  • 08 Sep 2026 Primary endpoint (Time-normalized (per 4 weeks) number of Investigator-confirmed HAE attacks during the 24-week Treatment Period) has been met, according to a Pharvaris media release.

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