Trial Profile

Phase 1b/2 Trial of Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 12 Jul 2025

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At a glance

Drugs Avutometinib (Primary) ; Defactinib (Primary) ; Encorafenib (Primary)
Indications Brain metastases; Malignant melanoma; Skin cancer
Focus Adverse reactions; Therapeutic Use
Acronyms DETERMINE

Most Recent Events

22 Feb 2024 Status changed from not yet recruiting to recruiting.
29 Jan 2024 Planned initiation date changed from 15 Jan 2024 to 15 Feb 2024.
10 Jan 2024 New trial record

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