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Effects of Ziltivekimab Versus Placebo on Heart Failure Symptoms and Physical Function in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation

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Trial Profile

Effects of Ziltivekimab Versus Placebo on Heart Failure Symptoms and Physical Function in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Feb 2026

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At a glance

  • Drugs Ziltivekimab (Primary)
  • Indications Heart failure; Inflammation
  • Focus Registrational; Therapeutic Use
  • Acronyms ATHENA
  • Sponsors Novo Nordisk

Most Recent Events

  • 23 Dec 2025 Planned End Date changed from 12 Jan 2027 to 10 Jan 2027.
  • 03 Jan 2025 Planned End Date changed from 10 Sep 2026 to 12 Jan 2027.
  • 03 Jan 2025 Planned primary completion date changed from 3 Jun 2026 to 5 Oct 2026.

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