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A Phase 1, Randomized, Double-blind, Placebo-controlled, First-in-human Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of VX-407 in Healthy Subjects

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Trial Profile

A Phase 1, Randomized, Double-blind, Placebo-controlled, First-in-human Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of VX-407 in Healthy Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 10 Jan 2026

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At a glance

  • Drugs VX 407 (Primary) ; Midazolam
  • Indications Autosomal dominant polycystic kidney disease
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Sponsors Vertex Pharmaceuticals

Most Recent Events

  • 14 Jul 2025 Status changed from active, no longer recruiting to completed.
  • 31 May 2025 Planned End Date changed from 30 Apr 2025 to 16 Jun 2025.
  • 31 May 2025 Status changed from completed to active, no longer recruiting.

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