Trial Profile

AN INTERVENTIONAL SAFETY AND EFFICACY PHASE 1B/2, OPEN-LABEL STUDY TO INVESTIGATE TOLERABILITY, PK, AND ANTITUMOR ACTIVITY OF VEPDEGESTRANT (ARV-471/PF-07850327), AN ORAL PROTEOLYSIS TARGETING CHIMERA, IN COMBINATION WITH PF-07220060 IN PARTICIPANTS AGED 18 YEARS AND OLDER WITH ER+/HER2- ADVANCED OR METASTATIC BREAST CANCER

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 17 Jul 2025

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At a glance

Drugs Atirmociclib (Primary) ; Vepdegestrant (Primary)
Indications Advanced breast cancer; HER2 negative breast cancer; Male breast cancer
Focus Adverse reactions; Therapeutic Use
Acronyms TACTIVE-K
Sponsors Pfizer

01 May 2025 Planned End Date changed from 13 Feb 2026 to 6 Mar 2026.
01 May 2025 Planned primary completion date changed from 14 Aug 2025 to 5 Sep 2025.
01 May 2025 Status changed from recruiting to active, no longer recruiting.

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