Trial Profile

A Phase 1 Open-label, First-in-human, Multi-center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of 225Ac-PSMA-Trillium in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 25 Jul 2025

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At a glance

28 Feb 2025 Planned number of patients changed from 135 to 235.
19 Dec 2024 Planned number of patients changed from 118 to 135.
15 May 2024 According to a Bayer media release, the company announced initiation of dosing in a Phase I first-in-human clinical study with 225Ac-PSMA-Trillium (BAY 3563254), a next-generation targeted alpha therapy.

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