A Phase 1, Multicenter, Single-arm, Dose-escalation Study of CC-97540 (BMS-986353), CD19-Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, Evaluating Safety and Tolerability in Participants With Relapsing Forms of Multiple Sclerosis (RMS) or Progressive Forms of Multiple Sclerosis (PMS)
Latest Information Update: 07 Aug 2026
At a glance
- Drugs Zolacaptagene autoleucel (Primary) ; Cyclophosphamide; Fludarabine
- Indications Multiple sclerosis
- Focus Adverse reactions
- Acronyms Breakfree-2
- Sponsors Juno Therapeutics
Most Recent Events
- 03 Aug 2026 Status changed from recruiting to active, no longer recruiting.
- 19 Jun 2026 This trial has been discontinued in Belgium, France, Germany, and Spain.
- 24 Jan 2025 Planned number of patients changed from 98 to 120.