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A Phase 1, Multicenter, Single-arm, Dose-escalation Study of CC-97540 (BMS-986353), CD19-Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, Evaluating Safety and Tolerability in Participants With Relapsing Forms of Multiple Sclerosis (RMS) or Progressive Forms of Multiple Sclerosis (PMS)

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Trial Profile

A Phase 1, Multicenter, Single-arm, Dose-escalation Study of CC-97540 (BMS-986353), CD19-Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, Evaluating Safety and Tolerability in Participants With Relapsing Forms of Multiple Sclerosis (RMS) or Progressive Forms of Multiple Sclerosis (PMS)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 05 Apr 2025

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At a glance

  • Drugs CC-97540 (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Multiple sclerosis
  • Focus Adverse reactions
  • Sponsors Juno Therapeutics

    • Most Recent Events

    • 24 Jan 2025 Planned number of patients changed from 98 to 120.
    • 19 Nov 2024 According to a Bristol Myers Squibb media release, results from this trial will be presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, to be held from December 7 to 10 in San Diego, California.
    • 29 Mar 2024 Planned initiation date (estimated date of first participant enrollment) changed from 5 Apr 2024 to 30 Apr 2024.

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