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An Open-label, Phase 1, Multicenter Study to Evaluate the Safety and Preliminary Anti-tumor Activity of NT-112 in Human Leukocyte Antigen-C*08:02-Positive Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for the KRAS G12D Mutation

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An Open-label, Phase 1, Multicenter Study to Evaluate the Safety and Preliminary Anti-tumor Activity of NT-112 in Human Leukocyte Antigen-C*08:02-Positive Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for the KRAS G12D Mutation

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 27 Dec 2024

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At a glance

  • Drugs NT 112 (Primary)
  • Indications Adenocarcinoma; Colorectal cancer; Endometrial cancer; Non-small cell lung cancer; Pancreatic cancer
  • Focus Adverse reactions; First in man
  • Sponsors AstraZeneca; Neogene Therapeutics

    • Most Recent Events

    • 24 Dec 2024 Planned End Date changed from 2 Jan 2040 to 30 Aug 2040.
    • 24 Dec 2024 Planned primary completion date changed from 30 Aug 2025 to 30 Aug 2027.
    • 04 Jun 2024 Trial design presented at the 60th Annual Meeting of the American Society of Clinical Oncology

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