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Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion: a Multi-center, Prospective, Open-label, Blinded Endpoint (PROBE), Phase 3, Randomized Controlled Trial

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Trial Profile

Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion: a Multi-center, Prospective, Open-label, Blinded Endpoint (PROBE), Phase 3, Randomized Controlled Trial

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 10 Dec 2025

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At a glance

  • Drugs Tenecteplase (Primary)
  • Indications Stroke
  • Focus Therapeutic Use
  • Acronyms TNK-PLUS

Most Recent Events

  • 10 Dec 2025 Status changed from recruiting to completed.
  • 16 May 2024 Status changed from active, no longer recruiting to recruiting.
  • 30 Jan 2024 New trial record

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