Trial Profile

A Phase 1 Trial Investigating LY4101174, an Antibody-Drug Conjugate Targeting Nectin-4, in Participants With Recurrent, Advanced or Metastatic Solid Tumors

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 13 Feb 2026

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At a glance

Drugs ETx 22 (Primary)
Indications Cervical cancer; Head and neck cancer; Male breast cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Prostate cancer; Squamous cell cancer; Triple negative breast cancer; Urogenital cancer
Focus Adverse reactions; First in man; Therapeutic Use
Acronyms EXCEED
Sponsors Eli Lilly and Company

Most Recent Events

22 Apr 2025 Planned End Date changed from 4 Mar 2027 to 1 Mar 2027.
22 Apr 2025 Planned primary completion date changed from 26 Aug 2026 to 1 Mar 2027.
10 Apr 2024 Trial design presented at the 115th Annual Meeting of the American Association for Cancer Research

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