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A Phase 1/2a Study to Evaluate the Safety, Pharmacokinetics and Efficacy of PTT-936, an Alpha Kinase 1 (ALPK1) Activator, Alone or in Combination With Anti-PD-1/L1 in Patients With Locally Advanced or Metastatic Solid Tumors

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A Phase 1/2a Study to Evaluate the Safety, Pharmacokinetics and Efficacy of PTT-936, an Alpha Kinase 1 (ALPK1) Activator, Alone or in Combination With Anti-PD-1/L1 in Patients With Locally Advanced or Metastatic Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 17 Mar 2025

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At a glance

  • Drugs PTT 936 (Primary) ; Programmed cell death 1 receptor antagonists; Programmed cell death-1 ligand-1 modulators
  • Indications Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Pyrotech Therapeutics

    • Most Recent Events

    • 12 Mar 2025 Number of treatment arms have been decreased from 10 to 6 by removing the arms for Dose levels 6,7 8 and 9.
    • 20 Feb 2024 Status changed from not yet recruiting to recruiting.
    • 12 Feb 2024 New trial record

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