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AN INTERVENTIONAL, PHASE 1, OPEN-LABEL, FIXED SEQUENCE, 2-PERIOD STUDY TO ESTIMATE THE EFFECT OF SINGLE AND MULTIPLE DOSES OF VEPDEGESTRANT (ARV-471, PF-07850327) ON THE PHARMACOKINETICS OF SINGLE DOSE MIDAZOLAM IN HEALTHY ADULT FEMALES OF NON-CHILDBEARING POTENTIAL.

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Trial Profile

AN INTERVENTIONAL, PHASE 1, OPEN-LABEL, FIXED SEQUENCE, 2-PERIOD STUDY TO ESTIMATE THE EFFECT OF SINGLE AND MULTIPLE DOSES OF VEPDEGESTRANT (ARV-471, PF-07850327) ON THE PHARMACOKINETICS OF SINGLE DOSE MIDAZOLAM IN HEALTHY ADULT FEMALES OF NON-CHILDBEARING POTENTIAL.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 16 Feb 2025

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At a glance

  • Drugs Vepdegestrant (Primary) ; Midazolam
  • Indications HER2 negative breast cancer
  • Focus Pharmacokinetics
  • Sponsors Pfizer

    • Most Recent Events

    • 11 Feb 2025 According to an Arvinas media release, data from this study were presented at the at the San Antonio Breast Cancer Symposium (SABCS) in December 2024.
    • 30 Oct 2024 According to an Arvinas media release, company plans to present data from the Phase 1 healthy volunteer pharmacokinetic trial of vepdegestrant in combination with midazolam to assess potential for drug-drug interaction at SABCS in December 2024.
    • 22 May 2024 Status changed from recruiting to completed.

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