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A Multicentre, Randomised, Double-blind, Placebo-controlled Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Combination Compared to Zibotentan Monotherapy, Zibotentan/Dapagliflozin and Zibotentan Monotherapy Compared to Placebo in Participants With Cirrhosis

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Trial Profile

A Multicentre, Randomised, Double-blind, Placebo-controlled Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Combination Compared to Zibotentan Monotherapy, Zibotentan/Dapagliflozin and Zibotentan Monotherapy Compared to Placebo in Participants With Cirrhosis

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 24 Mar 2025

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At a glance

  • Drugs Dapagliflozin (Primary) ; Dapagliflozin/zibotentan (Primary) ; Zibotentan (Primary)
  • Indications Liver cirrhosis
  • Focus Adverse reactions
  • Acronyms ZEAL-UNLOCK
  • Sponsors AstraZeneca

    • Most Recent Events

    • 20 Mar 2025 Status changed from active, no longer recruiting to completed.
    • 09 Dec 2024 Planned End Date changed from 17 Jan 2025 to 10 Dec 2024.
    • 09 Dec 2024 Planned primary completion date changed from 17 Jan 2025 to 10 Dec 2024.

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