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Phase I Study of Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors in Participants With Metastatic Solid Tumors With KRAS G12V Mutations

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Trial Profile

Phase I Study of Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors in Participants With Metastatic Solid Tumors With KRAS G12V Mutations

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 05 Mar 2025

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At a glance

  • Drugs AFNT 111 (Primary) ; Bendamustine; Cyclophosphamide; Fludarabine
  • Indications Adenocarcinoma; Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions

    • Most Recent Events

    • 21 Feb 2025 Planned End Date changed from 31 Dec 2025 to 9 Feb 2026.
    • 21 Feb 2025 Status changed from recruiting to active, no longer recruiting.
    • 10 Apr 2024 Trial design presented at the 115th Annual Meeting of the American Association for Cancer Research

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