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A Multi-center, Open-label Phase II Study of Lenvatinib Plus Pembrolizumab (LEAP) in Renal Cell Carcinoma Patients With Brain Metastasis Previously Treated With Immune Checkpoint Blockade

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Trial Profile

A Multi-center, Open-label Phase II Study of Lenvatinib Plus Pembrolizumab (LEAP) in Renal Cell Carcinoma Patients With Brain Metastasis Previously Treated With Immune Checkpoint Blockade

Status: Not yet recruiting
Phase of Trial: Phase II

Latest Information Update: 18 Jun 2025

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At a glance

  • Drugs Lenvatinib (Primary) ; Pembrolizumab (Primary)
  • Indications Brain metastases; Renal cell carcinoma
  • Focus Adverse reactions
  • Sponsors Merck Sharp & Dohme

Most Recent Events

  • 10 Jun 2025 Status changed from planning to not yet recruiting.
  • 18 Mar 2024 New trial record
  • 27 Jan 2024 Trial design presented at the 2024 Genitourinary Cancers Symposium

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