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A phase I trial to determine Givastomig in newly diagnosed (frontline treatment) gastric cancer and esophageal cancer in combination with chemotherapy and a checkpoint inhibitor

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Trial Profile

A phase I trial to determine Givastomig in newly diagnosed (frontline treatment) gastric cancer and esophageal cancer in combination with chemotherapy and a checkpoint inhibitor

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 10 Jun 2025

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At a glance

  • Drugs Givastomig (Primary) ; Nivolumab (Primary) ; Capecitabine; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Therapeutic Use
  • Sponsors I-MAB Biopharma

Most Recent Events

  • 03 Jun 2025 According to an I-Mab media release, the trial has been selected for a Mini Oral presentation at the ESMO GI Cancers Congress, scheduled for July 2, 2025.
  • 15 May 2025 According to an I-Mab media release, dose escalation combination data on U.S. patients will be presented at the European Society of Medical Oncology Gastrointestinal Cancers Congress 2025, being held July 2-5 in Barcelona, Spain.
  • 30 Apr 2025 According to an I-Mab media release, the company announced that an abstract for a combination study of givastomig plus nivolumab and chemotherapy has been accepted for a mini-oral presentation at the ESMO Gastrointestinal Cancers Congress 2025, which will be held July 2-5 in Barcelona, Spain.

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