Trial Profile

A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Three-arm Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tarcocimab Tedromer and Tabirafusp Tedromer Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 30 Oct 2025

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At a glance

Drugs Tabirafusp tedromer (Primary) ; Tarcocimab tedromer (Primary) ; Aflibercept
Indications Wet age-related macular degeneration
Focus Therapeutic Use
Acronyms DAYBREAK
Sponsors Kodiak Sciences

27 Oct 2025 Planned End Date changed from 1 Apr 2027 to 1 Aug 2027.
27 Oct 2025 Planned primary completion date changed from 1 Apr 2026 to 1 Aug 2026.
27 Oct 2025 Status changed from recruiting to active, no longer recruiting.

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