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A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Three-arm Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tarcocimab Tedromer and Tabirafusp Tedromer Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

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Trial Profile

A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Three-arm Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tarcocimab Tedromer and Tabirafusp Tedromer Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 07 Feb 2025

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At a glance

  • Drugs Tabirafusp tedromer (Primary) ; Tarcocimab tedromer (Primary) ; Aflibercept
  • Indications Wet age-related macular degeneration
  • Focus Therapeutic Use
  • Acronyms DAYBREAK
  • Sponsors Kodiak Sciences
  • Most Recent Events

    • 03 Feb 2025 Planned End Date changed from 1 Jan 2026 to 1 Apr 2027.
    • 03 Feb 2025 Planned primary completion date changed from 1 Jan 2026 to 1 Apr 2026.
    • 14 Nov 2024 According to Kodiak Sciences media release, the company expects to complete this trial in the first half of 2025.

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