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A Randomized Phase 2 Study Assessing the Efficacy and Safety of Olvimulogene Nanivacirepvec Followed by Platinum-doublet Chemotherapy + Physician's Choice of Immune Checkpoint Inhibitor Compared with Docetaxel in Patients with NSCL Cancer After First Progression While on Front-line Immune Checkpoint Inhibitor-based Maintenance

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Trial Profile

A Randomized Phase 2 Study Assessing the Efficacy and Safety of Olvimulogene Nanivacirepvec Followed by Platinum-doublet Chemotherapy + Physician's Choice of Immune Checkpoint Inhibitor Compared with Docetaxel in Patients with NSCL Cancer After First Progression While on Front-line Immune Checkpoint Inhibitor-based Maintenance

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 09 Dec 2025

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At a glance

  • Drugs Atezolizumab (Primary) ; Carboplatin (Primary) ; Cemiplimab (Primary) ; Cisplatin (Primary) ; Durvalumab (Primary) ; Nivolumab (Primary) ; Olvimulogene nanivacirepvec (Primary) ; Paclitaxel (Primary) ; Pembrolizumab (Primary) ; Pemetrexed (Primary) ; Docetaxel
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Therapeutic Use
  • Acronyms VIRO-25
  • Sponsors Genelux Corporation

Most Recent Events

  • 05 Nov 2025 According to a Genelux Corporation media release, interim data expected in fourth quarter of 2025 and throughout 2026.
  • 06 May 2025 According to a Genelux Corporation media release, patient enrollment has been increasing in this study with an interim readout anticipated in 2H 2025.
  • 14 Nov 2024 According to a Genelux Corporation media release, data from this Phase 2 trial in NSCLC expected by mid-2025.

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