Trial Profile

A Multicenter, Randomised, Comparative, Open-label Phase III Aiming to Compare the Survival of Patients With Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas Treated by a Combination of Immune Checkpoint Inhibitors (Botensilimab + Balstilimab) Versus the Standard of Care (FOLFOX/XELOX + Nivolumab)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 19 Dec 2025

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At a glance

Drugs Balstilimab (Primary) ; Botensilimab (Primary) ; Capecitabine; Fluorouracil; Folinic acid; Nivolumab; Oxaliplatin
Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
Focus Registrational; Therapeutic Use
Acronyms CIME

16 Dec 2025 Status changed from not yet recruiting to recruiting.
18 Nov 2025 Planned number of patients changed from 124 to 132.
18 Nov 2025 Planned initiation date changed from 15 Oct 2024 to 15 Dec 2025.

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