Trial Profile

A Phase I/II Single-arm Trial of Azenosertib (ZN-c3) Combined With Carboplatin and Pembrolizumab in Patients With Metastatic Triple-negative Breast Cancer (ZAP-IT)

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 16 Jan 2026

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At a glance

Drugs Azenosertib (Primary) ; Carboplatin (Primary) ; Pembrolizumab (Primary)
Indications Advanced breast cancer; Triple negative breast cancer
Focus Adverse reactions; Therapeutic Use
Acronyms ZAP-IT

12 Jan 2026 Status changed from recruiting to active, no longer recruiting.
18 Dec 2024 Status changed from suspended to recruiting.
16 Sep 2024 According to Zentalis Pharmaceuticals media release, company announced that the U.S. Food and Drug Administration (FDA) has lifted the partial clinical hold on studies of azenosertib.The FDA has cleared the Company to resume enrollment in all ongoing azenosertib clinical studies with no changes in the clinical development plan.

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