Trial Profile

MK-5684-01A Substudy: A Phase 1/2 Umbrella Substudy of MK-5684-U01 Master Protocol to Evaluate the Safety and Efficacy of MK-5684-based Treatment Combinations or MK-5684 Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC)

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 09 Jun 2025

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At a glance

Drugs Cabazitaxel (Primary) ; Docetaxel (Primary) ; Olaparib (Primary) ; Opevesostat (Primary)
Indications Adenocarcinoma; Prostate cancer
Focus Adverse reactions; Therapeutic Use
Acronyms CYPIDES study; Substudy 01A
Sponsors Merck Sharp & Dohme

17 Sep 2024 Trial design presented at the 49th European Society for Medical Oncology Congress
23 May 2024 Status changed from not yet recruiting to recruiting.
11 Apr 2024 New trial record

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