Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases: A Randomized, Controlled, Multicenter Phase II Trial
Latest Information Update: 03 Jul 2025
At a glance
- Drugs Fruquintinib (Primary) ; Regorafenib (Primary) ; Sintilimab (Primary)
- Indications Adenocarcinoma; Colorectal cancer; Liver metastases
- Focus Therapeutic Use
- Acronyms FREST-CRC
Most Recent Events
- 26 Jun 2025 Study protocol amended with addition of liver Metastases patients. Arms increased from 2 to 3. Drug regorafenib removed from study intervention.
- 26 Jun 2025 Planned number of patients changed from 57 to 62.
- 29 Jan 2025 Planned number of patients changed from 141 to 57.