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A Randomized, Participant & Investigator Blinded, Placebo-Controlled Study to Evaluate the Ability of Intrathecally Administered NIO752 to Lower CSF Total Tau Synthesis in Participants With AD Measured by Stable Isotope Labelling Kinetics

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Trial Profile

A Randomized, Participant & Investigator Blinded, Placebo-Controlled Study to Evaluate the Ability of Intrathecally Administered NIO752 to Lower CSF Total Tau Synthesis in Participants With AD Measured by Stable Isotope Labelling Kinetics

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 12 Aug 2025

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At a glance

  • Drugs NIO 752 (Primary)
  • Indications Alzheimer's disease
  • Focus Therapeutic Use
  • Acronyms NIO-SILK

Most Recent Events

  • 30 Jul 2025 Planned End Date changed from 1 Aug 2025 to 1 Jul 2026.
  • 30 Jul 2025 Planned primary completion date changed from 1 Feb 2025 to 1 Jul 2026.
  • 30 Jul 2025 Status changed from not yet recruiting to recruiting.

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