Trial Profile

A Phase 1 Open-label Study to Assess the Safety and Tolerability of Zolbetuximab (IMAB362) in Combination With Chemotherapy (mFOLFIRINOX) in Participants With CLDN18.2 Positive Metastatic Pancreatic Adenocarcinoma

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 17 Nov 2025

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At a glance

Drugs Fluorouracil (Primary) ; Folinic acid (Primary) ; Irinotecan (Primary) ; Oxaliplatin (Primary) ; Zolbetuximab (Primary)
Indications Adenocarcinoma; Pancreatic cancer
Focus Adverse reactions
Sponsors Astellas Pharma Global Development

13 Nov 2025 Status changed from recruiting to active, no longer recruiting.
20 Oct 2025 Planned End Date changed from 3 Jul 2026 to 31 Jul 2026.
20 Oct 2025 Planned primary completion date changed from 3 Jul 2026 to 31 Jul 2026.

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