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A Phase 1/2 Multicenter, Open-label, Dose Escalation, Safety and Efficacy Study of Subretinal Administration of Dual AAV8.MYO7A, AAVB-081 in Subjects With Usher Syndrome Type IB (USH1B) Retinitis Pigmentosa

Trial Profile

A Phase 1/2 Multicenter, Open-label, Dose Escalation, Safety and Efficacy Study of Subretinal Administration of Dual AAV8.MYO7A, AAVB-081 in Subjects With Usher Syndrome Type IB (USH1B) Retinitis Pigmentosa

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 19 May 2025

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At a glance

  • Drugs AAVB 081 (Primary)
  • Indications Usher syndrome type 1B
  • Focus Adverse reactions; First in man
  • Acronyms LUCE-1
  • Sponsors AAVantgarde Bio

Most Recent Events

  • 12 May 2025 According to AAVantgarde Bio media release, updated positive safety results in 8 patients and day 180 results for first subject dosed , presented at the Association for Research in Vision and Ophthalmology Annual Meeting (ARVO), held May 4-8, 2025 in Salt Lake City (US).
  • 12 May 2025 Results presented in the AAVantgarde Bio Media Release
  • 10 Mar 2025 According to AAVantgarde Bio media release, the oral presentation from this trial will be presented at the Association for Research in Vision and Ophthalmology Annual Meeting (ARVO), to be held May 4-8, 2025 in Salt Lake City (US).

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